Recent Advances in Glucocorticoid Receptor Action by A. Cato (English) Paperback

Description: Recent Advances in Glucocorticoid Receptor Action by A. Cato, H. Schaecke, K. Asadullah Since 1948, hydrocortisone (cortisol), the principal glucocorticoid (GC) of the human adrenal cortex has been successfully used at pharÂ macological concentrations for the suppression of clinical manifestaÂ tions of rheumatoid arthritis. Numerous compounds with GC activity have also been developed and used. Fifty years after their initial clinical use, GCs are still the most imÂ portant and frequently prescribed class of anti-inflammatory drugs for various inflammatory disorders. They are administered either orally, parenterally (intravenous, intramuscular, intrathecal), or topically (cuÂ taneous, intranasal, pulmonic, rectal). Despite the many beneficial efÂ fects of GCs, they also have their limitations and disadvantages that occur with varying prevalence on different organs and after different durations of therapy. These side-effects can range in severity from cosÂ metic (e.g. telangiectasias, hypertrichosis) to seriously disabling (e.g. induction of glaucoma, diabetes, osteoporosis) or even life-threatening disorders (e.g. gastric haemorrhage). These adverse effects of GCs seÂ riously handicap their successful use as anti-inflammatory agents. There is therefore a strong need for the development of substances with the anti-inflammatory potency of classical GCs but with reduced side-e FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Since 1948, hydrocortisone (cortisol), the principal glucocorticoid (GC) of the human adrenal cortex has been successfully used at phar- macological concentrations for the suppression of clinical manifesta- tions of rheumatoid arthritis. Numerous compounds with GC activity have also been developed and used. Fifty years after their initial clinical use, GCs are still the most im- portant and frequently prescribed class of anti-inflammatory drugs for various inflammatory disorders. They are administered either orally, parenterally (intravenous, intramuscular, intrathecal), or topically (cu- taneous, intranasal, pulmonic, rectal). Despite the many beneficial ef- fects of GCs, they also have their limitations and disadvantages that occur with varying prevalence on different organs and after different durations of therapy. These side-effects can range in severity from cos- metic (e.g. telangiectasias, hypertrichosis) to seriously disabling (e.g. induction of glaucoma, diabetes, osteoporosis) or even life-threatening disorders (e.g. gastric haemorrhage). These adverse effects of GCs se- riously handicap their successful use as anti-inflammatory agents.There is therefore a strong need for the development of substances with the anti-inflammatory potency of classical GCs but with reduced side-effects. Table of Contents 1 Glucocorticoids and Asthma.- 2 Immune Monitoring of Glucocorticoid Therapy.- 3 Topical Glucocorticoid Therapy in Dermatology.- 4 Bone Effects of Glucocorticoid Therapy.- 5 Corticosteroids in Ophthalmology.- 6 Special Problems in Glucocorticoid Treatment in Children.- 7 Functional Implications of Glucocorticoid Receptor Trafficking.- 8 The Dynamics of Intranuclear Movement and Chromatin Remodeling by the Glucocorticoid Receptor.- 9 Glucocorticoid Receptor Antagonism of AP-1 Activity by Inhibition of MAPK Family.- 10 Mast Cells as Targets for Glucocorticoids in the Treatment of Allergic Disorders.- 11 Cytosolic Glucocorticoid Receptor-Interacting Proteins.- 12 The Glucocorticoid Receptor ?-Isoform: A Perspective on Its Relevance in Human Health and Disease.- 13 Cooperation of Nuclear Transcription Factors Regulated by Steroid and Peptide Hormones.- 14 Induction and Repression of NF-?B-Driven Inflammatory Genes.- 15 DNA-Dependent Cofactor Selectivity of the Glucocorticoid Receptor.- 16 The Anti-inflammatory Action of Glucocorticoid Hormones.- 17 Analysis of Glucocorticoid Receptor Function in the Mouse by Gene Targeting.- 18 Glucocorticoid-Inducible Genes That Regulate T-Cell Function.- 19 Structural Analysis of the GR Ligand-Binding Domain.- 20 SEGRAs: A Novel Class of Anti-inflammatory Compounds.- Previous Volumes Published in This Series. Promotional Springer Book Archives Long Description Since 1948, hydrocortisone (cortisol), the principal glucocorticoid (GC) of the human adrenal cortex has been successfully used at phar Details ISBN3662046628 Language English Edition 02200th ISBN-10 3662046628 ISBN-13 9783662046623 Series Ernst Schering Foundation Symposium Proceedings Year 2013 Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K Place of Publication Berlin Country of Publication Germany Edited by K. Asadullah DEWEY 611.01816 Short Title RECENT ADVANCES IN GLUCOCORTIC Media Book Series Number 40 Publication Date 2013-10-03 UK Release Date 2013-10-03 Author K. Asadullah Pages 380 Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Edition Description Softcover reprint of the original 1st ed. 2002 Format Paperback Alternative 9783540432296 Audience Professional & Vocational Illustrations 12 Illustrations, color; 56 Illustrations, black and white; XXI, 380 p. 68 illus., 12 illus. in color. 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