Description: Title: Cell Type: Medical Journal Publisher: Cell Press / Cell Press Journals Frequency: Bi-Weekly Volume: 177 Issue Number: 5 Date Released: May 16, 2019 Features: ColorfulResourcefulInformative & Cutting-Edge Peer Reviewed Studies!Table of Contents: Leading Edge ■ ■ OBITUARY ■ ■ 1081 ➥ Sydney Brenner (1927-2019) ➥ by M. Cobb ■ ■ PREVIEWS ■ ■1084 ➥ Drowning in Viruses ➥ by S.A. Handley and H.W. Virgin1086 ➥ "Breathing" Hemagglutinin Reveals Cryptic Epitopes for Universal Influenza Vaccine Design ➥ by Y. Wu and G.F. Gao1088 ➥ Overriding the Immune System's Sweet Tooth: Fatty Acids Rile Up Innate Immunity ➥ by A.C. Billi and J.E. Gudjonsson1091 ➥ Star Power: Astrocytes Regulate Behavior ➥ by N.J. Allen■ ■ PERSPECTIVE ■ ■ 1094 ➥ The Coming Decade of Cell Death Research: Five Riddles ➥ by D.R. Green■ ■ PREVIEWS ■ ■1109 ➥ Marine DNA Viral Macro- and Microdiversity from Pole to Pole ➥ by A.C. Gregory, A.A. Zayed, N. Conceicao-Neto, B. Temperton, B. Bolduc, A. Alberti, M. Ardyna, K. Arkhipova, M. Carmichael, C. Cruaud, C. Dimier, G. Dominguez-Huerta, J. Ferland, S. Kandels, Y. Liu, C. Marec, S. Pesant, M. Picheral, S. Pisarev, J. Poulain, J.-E. Tremblay, D. Vik, Tara Oceans Coordinators, M. Babin, C. Bowler, A.I. Culley, C. de Vargas, B.E. Dutilh, D. Iudicone, L. Karp-Boss, S. Roux, S. Sunagawa, P. Wincker, and M.B. Sullivan1124 ➥ Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism ➥ by A. Watanabe, K.R. McCarthy, M. Kuraoka, A.G. Schmidt, Y. Adachi, T. Onodera, K. Tonouchi, T.M. Caradonna, G. Bajic, S. Song, C.E. McGee, G.D. Sempowski, F. Feng, P. Urick, T.B. Kepler, Y. Takahashi, S.C. Harrison, and G. Kelsoe1136 ➥ A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface ➥ by S. Bangaru, S. Lang, M. Schotsaert, H.A. Vanderven, X. Zhu, N. Kose, R. Bombardi, J.A. Finn, S.J. Kent, P. Gilchuk, I. Gilchuk, H.L. Turner, A. Garcia-Sastre, S. Li, A.B. Ward, I.A. Wilson, and J.E. Crowe, Jr.1153 ➥ Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance ➥ by K.M. Cirelli, D.G. Carnathan, B. Nogal, J.T. Martin, O.L. Rodriguez, A.A. Upadhyay, C.A. Enemuo, E.H. Gebru, Y. Choe, F. Viviano, C. Nakao, M.G. Pauthner, S. Reiss, C.A. Cottrell, M.L. Smith, R. Bastidas, W. Gibson, A.N. Wolabaugh, M.B. Melo, B. Cossette, V. Kumar, N.B. Patel, T. Tokatlian, S. Menis, D.W. Kulp, D.R. Burton, B. Murrell, W.R. Schief, S.E. Bosinger, A.B. Ward, C.T. Watson, G. Silvestri, D.J. Irvine, and S. Crotty1172 ➥ Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells ➥ by Y. Miao, H. Yang,J. Levorse, S. Yuan, L. Polak, M. Sribour, B. Singh, M.D. Rosenblum, and E. Fuchs1187 ➥ Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity ➥ by C. Cadena, S. Ahmad, A. Xavier, J. Willemsen, S. Park, J.W. Park, S.-W. Oh, T. Fujita, F. Hou, M. Binder, and S. Hur1201 ➥ Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR ➥ by D.A. Mogilenko, J.T. Haas, L. L'homme, S. Fleury, S. Quemener, M. Levasseur, C. Becquart, J. Wartelle, A. Bogomolova, L. Pineau, O. Molendi-Coste, S. Lancel, H. Dehondt, C. Gheeraert, A. Melchior, C. Dewas, A. Nikitin, S. Pic, N. Rabhi, J.-S. Annicotte, S. Oyadomari, T. Velasco-Hernandez, J. Cammenga, M. Foretz, B. Viollet, M. Vukovic, A. Villacreces, K. Kranc, P. Carmeliet, G. Marot, A. Boulter, S. Tavernier, L. Berod, M.P. Longhi, C. Paget, S. Janssens, D. Staumont-Salle, E. Aksoy, B. Staels, and D. Dombrowicz1217 ➥ A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology ➥ by H. Chen, P.-K. Nwe, Y. Yang, C.E. Rosen, A.A. Bielecka, M. Kuchroo, G.W. Cline, A.C. Kruse, A.M. Ring, J.M. Crawford, and N.W. Palm1232 ➥ Assembly of a GPCR-G Protein Complex ➥ by Y. Du, N.M. Duc, S.G.F. Rasmussen, D. Hilger, X. Kubiak, L. Wang, J. Bohon, H.R. Kim, M. Wegrecki, A. Asuru, K.M. Jeong, J. Lee, M.R. Chance, D.T. Lodowski, B.K. Kobilka, and K.Y. Chung1243 ➥ Structural Insights into the Process of GPCR-G Protein Complex Formation ➥ by X. Liu, X. Xu, D. Hilger, P. Aschauer, J.K.S. Tiemann, Y. Du, H. Liu, K. Hirata, X. Sun, R. Guixa-Gonzalez, J.M. Mathiesen, P.W. Hildebrand, and B.K. Kobilka1252 ➥ Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter ➥ by Y. Wang, N.X. Nguyen, J. She, W. Zeng, Y. Yang, X.-c. Bai, and Y. Jiang1262 ➥ Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke ➥ by I. Alim, J.T. Caulfield, Y. Chen, V. Swarup, D.H. Geschwind, E. Ivanova, J. Seravalli, Y. Ai, L.H. Sansing, E.J. Ste.Marie, R.J. Hondal, S. Mukherjee, J.W. Cave, B.T. Sagdullaev, S.S. Karuppagounder, and R.R. Ratan1280 ➥ Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue ➥ by J. Nagai, A.K. Rajbhandari, M.R. Gangwani, A. Hachisuka, G. Coppola, S.C. Masmanidis, M.S. Fanselow, and B.S. Khakh1293 ➥ An Excitatory Circuit in the Perioculomotor Midbrain for Non-REM Sleep Control ➥ by Z. Zhang, P. Zhong, F. Hu, Z. Barger, Y. Ren, X. Ding, S. Li, F. Weber, S. Chung, R.D. Palmiter, and Y. Dan1308 ➥ Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals ➥ by N. Romanov, M. Kuh, R. Aebersold, A. Ori, M. Beck, and P. Bork ■ ■ RESOURCES ■ ■1319 ➥ Profiling of Pluripotency Factors in Single Cells and Early Embryos ➥ by S.J. Hainer, A. Boskovic, K.N. McCannell, O.J. Rando, and T.G. Fazzio1330 ➥ A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer ➥ by J.Wagner, M.A. Rapsomaiki, S. Chevrier, T. Anzeneder, C. Langwieder, A. Dykgers, M. Rees, A. Ramaswamy, S. Muenst, S.D. Soysal, A. Jacobs, J. Windhager, K. Silina, M. van den Broek, K.J. Dedes, M. Rodriguez Martinez, W.P. Weber, and B. Bodenmiller1346 ➥ Rational Engineering of XCaMPs, a Multicolor GECI Suite for In Vivo Imaging of Complex Brain Circuit Dynamics ➥ by M. Inoue, A. Takeuchi, S. Manita, S.-i. Horigane, M. Sakamoto, R. Kawakami, K. Yamaguchi, K. Otomo, H. Yokoyama, R. Kim, T. Yokoyama, S. Takemoto-Kimura, M. Abe, M. Okamura, Y. Kondo, S. Quirin, C. Ramakrishnan, T. Imamura, K. Sakimura, T. Nemoto, M. Kano, H. Fujii, K. Deisseroth, K. Kitamura, and H. Bito■ ■ ANNOUNCEMENTS ■ ■ ■ ■ POSITIONS AVAILABLE ■ ■ ■ ■ ON THE COVER ■ ■ ➥ The global diversity of viruses across continents and oceans is vast and yet poorly catalogued and understood. (North Pole) In this issue of Cell, Gregory et al. (1109-1123) sample and sequence viral genomes across global oceans, including the Arctic, and suggest that the Arctic is an underexplored biodiversity hotspot for viruses. The cover photo shows the schooner Tara sailing by an iceberg in Greenland during its circumnavigation of the Arctic Ocean in 2013 at the end of the three-year Tara Oceans expedition. Image credit: F. Aurat/taraexpeditions . org Origin: Cambridge, Massachusetts (MA) Country: Printed in the USA / United States / U.S.A. Condition: Like New! We Accept Offers!
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Publication Month: May
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Publication Frequency: Biweekly
Issue Number: 5
Volume: 177
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